Simultaneous phylogeny reconstruction and multiple sequence alignment
نویسندگان
چکیده
منابع مشابه
HandAlign: Bayesian multiple sequence alignment, phylogeny and ancestral reconstruction
UNLABELLED We describe handalign, a software package for Bayesian reconstruction of phylogenetic history. The underlying model of sequence evolution describes indels and substitutions. Alignments, trees and model parameters are all treated as jointly dependent random variables and sampled via Metropolis-Hastings Markov chain Monte Carlo (MCMC), enabling systematic statistical parameter inferenc...
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Preface Since the identification of DNA/RNA as genetic material, deciphering the code of life has been a major goal put forward by biologists. One approach particularly successful in studying DNA sequences is to compare related sequences from different organisms. Sequence alignment, specifically pairwise alignment, is among the earliest tool developed in bioinformatics. However, the generalizat...
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One of the main problems in computational biology is the construction of biologically plausible alignments for given sequence families. Many procedures have been developed for this purpose; most are based on clustering the sequences hierarchically prior to the computation of their alignment and then proceeding recursively. In this paper, we compare results obtained with a new algorithm for simu...
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ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2009
ISSN: 1471-2105
DOI: 10.1186/1471-2105-10-s1-s11